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Inventi Impact: Novel Excipients

Articles

  • Inventi:pne/30713/19
    Intracellular Delivery of Natural Antioxidants via Hyaluronan Nanohydrogels
    Research 2020 : January - March
    Elita Montanari, Chiara Di Meo, Tommasina Coviello, Virginie Gueguen, Graciela Pavon-Djavid, Pietro Matricardi

    Natural antioxidants, such as astaxanthin (AX), resveratrol (RV) and curcumin (CU),\nare bioactive molecules that show a number of therapeutic effects. However, their applications are\nremarkably limited by their poor water solubility, physico-chemical instability and low bioavailability.\nIn the present work, it is shown that self-assembled hyaluronan (HA)-based nanohydrogels (NHs)\nare taken up by endothelial cells (Human Umbilical Vein Endothelial Cells, HUVECs), preferentially\naccumulating in the perinuclear area of oxidatively stressed HUVECs, as evidenced by flow cytometry\nand confocal microscopy analyses. Furthermore, NHs are able to physically entrap and to significantly\nenhance the apparent water solubility of AX, RV and CU in aqueous media. AX/NHs, RV/NHs and\nCU/NHs systems showed good hydrodynamic diameters (287, 214 and 267 nm, respectively), suitable����������

    How to Cite this Article
    Attribution/ CC Compliant Citation: Montanari, Elita, et al. \"Intracellular Delivery of Natural Antioxidants via Hyaluronan\nNanohydrogels.\" Pharmaceutics 11.10 (2019): 532.\nhttps://doi:10.3390/pharmaceutics11100532\nhttp://creativecommons.org/licenses/by/4.0/\n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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